Secuelas post covid - 19 y mortalidad asociada en pacientes con insuficiencia renal
Palabras clave:
Pacientes renales; enfermedad; Pandemia; consecuencias.
Resumen
La enfermedad causada por el nuevo coronavirus SARS-CoV-2 es el COVID-19, según la Organización Mundial de la Salud es una enfermedad infecciosa de gran importancia. Las personas con insuficiencia renal han sido afectadas a nivel mundial por este virus. Es por ello que este trabajo tiene como objetivo evaluar las evidencias científicas sobre las secuelas post COVID-19 y la mortalidad asociada en pacientes con insuficiencia renal. La investigación posee un diseño de tipo documental con un alcance explicativo basado en la búsqueda de información relevante en relación al estudio en curso, para la búsqueda especifica se utilizaron bases de datos científicas provenientes de: PubMed, SciELO, Elsevier, Scopus, Latindex, en las cuales se utilizaron los términos MeSH como: “Insuficiencia Renal”, “Renal Insuficiency, “Coronavirus Covid-19, “Clinical diagnosis”. solo 109 artículos fueron de utilidad para el estudio. Sin embargo, solo 45 artículos científicos resultaron de alto impacto para el desarrollo de los objetivos. Entre los resultados se puede señalar que, el COVID-19 está asociado con altas tasas de problema renales, que son derivados de esta enfermedad, así mismo, las principales secuelas post COVID-19 en pacientes con insuficiencia renal posterior a la alta médica evidencian diálisis, proteinuria en rango nefrótico, glomerulopatía colapsante, lesión tubular aguda aislada, glomerulopatía membranosa y terapia de trasplante renal. Se puede concluir que la prevalencia de pacientes con insuficiencia renal afectados por el COVID-19 es alta y la asociación entre la enfermedad y el desarrollo de complicaciones renales entre otra secuela y comorbilidades, incrementan probabilidades de mortalidad significativamente.
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1. OMS. WHO Coronavirus (COVID-19) Dashboard. , Organizacion Mundial de la Salud; 2021 Julio 21.
2. OMS. Coronavirus. , Organizacion Mundial de la Salud; 2021.
3. Orús A. Número de casos confirmados de coronavirus en el mundo a fecha de 3 de junio de 2022, por país. Statista, Salud e industria farmacéutica, Estado de salud; 2022.
4. Statista Research Department. Número de casos confirmados de coronavirus (COVID-19) en América Latina y el Caribe al 1 de junio de 2022, por país. Statista, Salud e industria farmacéutica, Estado de salud; 2022.
5. Martin Á, Fernández G. Enfermedad renal en la COVID-19 persistente: un objetivo inmediato para Nefrología. Nefrologia. 2022; 1.
6. Ponce-Lino L, Muñiz-Tóala S, Mastarreno-Cedeño M. Secuelas que enfrentan los pacientes que superan el COVID 19. Revista Cientifica Mundo de la Investigacion y el Conocimiento. 2020 Julio; 4(3): p. 153-162.
7. MSP. Situación epidemiológica nacional Covid-19, Ecuador. Ministerio de Salud Publica , Informes de Situación (SITREP); 2022.
8. Jiang D, McCoy R. Planning for the Post-COVID Syndrome: How Payers Can Mitigate Long-Term Complications of the Pandemic. J Gen Intern Med. 2020 Octubre; 35(10): p. 3036-3039.
9. Del Pino M, Salgueira M, Sanchez J. Registro de la Sociedad Española de Nefrologia sobre IRA en COVID-19. Sociedad Española de Nefrologia. 2021; 1.
10. Stephany L, Caballero-Uribe C, Lewis V. Consideraciones éticas en la publicación de investigaciones científicas. Salud Uninorte. 2017.
11. Organizacion Mundial de la Salud. [Online].; 2022 [cited 2022 Agosto 20. Available from: https://covid19.who.int/.
12. Russo E, Esposito P, Taramasso L, Magnasco L, Saio M, Briano F. Kidney disease and all-cause mortality in patients with COVID-19 hospitalized in Genoa, Northern Italy. Journal of Nephrology. 2021; 34(1): p. 173-183.
13. Chan L, Chaudhary K, Saha A. AKI in Hospitalized Patients with COVID-19. Observational Study. 2021; 32(1).
14. Moledina D, Simonov M, Yamamot Y. The Association of COVID-19 With Acute Kidney Injury Independent of Severity of Illness: A Multicenter Cohort Study. Am J Kidney Dis. 2021; 77(4).
15. Arikan H, Ozturk S, Tokgoz B. Characteristics and outcomes of acute kidney injury in hospitalized COVID-19 patients: A multicenter study by the Turkish society of nephrology. Observational Study. 2021; 16(8).
16. Öztürk S, Turgutalp K, Arıcı M. Impact of hospital-acquired acute kidney injury on Covid-19 outcomes in patients with and without chronic kidney disease: a multicenter retrospective cohort study. Turk J Med Sci. 2021; 28(51).
17. Cassol C, Hannoudi A, Larsen C. A multi-center retrospective cohort study defines the spectrum of kidney pathology in Coronavirus 2019 Disease (COVID-19). Kidney Int. 2021; 100(6).
18. Casas-Aparicio G, León-Rodríguez I, Alvarado-de la Barrera C. Acute kidney injury in patients with severe COVID-19 in Mexico. PLoS One. 2021; 16(2).
19. Costa R, Sória T, Salles E. Acute kidney injury in patients with Covid-19 in a Brazilian ICU: incidence, predictors and in-hospital mortality. J Bras Nefrol. 2021; 43(3).
20. Ryang K, Ri H, Ham Y. Acute Kidney Injury and Kidney Damage in COVID-19 Patients. J Korean Med Sci. 2020; 35(28).
21. Kari J, Shalaby M, Albanna A. Acute kidney injury in children with COVID-19: a retrospective study. BMC. 2021; 22(1).
22. Kolhe N, Fluck R, Nicholas M. Acute kidney injury associated with COVID-19: A retrospective cohort study. PLoS Med. 2020; 17(10): p. e1003406.
23. Zahid U, Ramachandran P, Spita S. Acute Kidney Injury in COVID-19 Patients: An Inner City Hospital Experience and Policy Implications. Soy J Nephrol. 2020; 21(10).
24. Sang L, Chen S, Zheng X. The incidence, risk factors and prognosis of acute kidney injury in severe and critically ill patients with COVID-19 in mainland China: a retrospective study. BMC Pulm Med. 2020; 20(1).
25. Nugent J, Aklilu A, Yamamoto Y, Simonov M, Li F. Assessment of Acute Kidney Injury and Longitudinal Kidney Function After Hospital Discharge Among Patients With and Without COVID-19. JAMA. 2021; 4(3).
26. Bowe B, Cai M, Xie Y, Gibson A, Maddukuri G, Al-Aly Z. Acute kidney injury in a national cohort of hospitalized US veterans with COVID-19. Clinical Journal of the American Society of Nephrology. 2021; 16(1): p. 14-25.
27. Stockmann H, Hardenberg J, Aigner A, Hinze C, Gotthardt I, Stier B, et al. High rates of long-term renal recovery in survivors of coronavirus disease 2019–associated acute kidney injury requiring kidney replacement therapy. Kidney International. 2021; 99(4): p. 1021-1022.
28. Hirsch J, Hazzan A, Wanchoo R, Shah H, Malieckal D, Ross D. Outcomes Among Patients Hospitalized With COVID-19 and Acute Kidney Injury. American Journal of Kidney Diseases. 2021; 77(2): p. 204-215.
29. Bowe B, Xie Y, Xu E. Kidney Outcomes in Long COVID. JASN. 2021; 32(11): p. 2851-2862.
30. Stevens J, King K, Robbins S, Khairallah P, Toma K, Verduzco H. High rate of renal recovery in survivors of COVID-19 associated acute renal failure requiring renal replacement therapy. PLOS ONE. 2020; 15(12).
31. Gameiro J, Fonseca J, Hospitalar C, Norte L, Oliveira J, Marques F, et al. Acute kidney injury in hospitalized patients with COVID-19. Research Square. 2020.
32. Gupta S, Hayek S, Wang W, Chan L, Mathews K, Melamed M, et al. Factors Associated With Death in Critically Ill Patients With Coronavirus Disease 2019 in the US. JAMA Internal Medicine. 2020; 180(11): p. 1436-1447.
33. Kudose S, Batal I, Santoriello D, Xu K, Barasch J, Peleg Y. Kidney Biopsy Findings in Patients with COVID-19. Journal of the American Society of Nephrology. 2020; 31(9): p. 1959-1968.
34. Sharma H, Behera M, Bhadauria D, Khushwaha R, Yachha M. High mortality and residual kidney damage with Coronavirus disease-19-associated acute kidney injury in northern India. Clinical and Experimental Nephrology. 2022;: p. 1-11.
35. Appelman B, Oppelaar J, Broeders L, Wiersinga W, Vogt L, Appelman B. Mortality and readmission rates among hospitalized COVID-19 patients with varying stages of chronic kidney disease: a multicenter retrospective cohort. Scientific Reports. 2022; 12(1): p. 1-8.
36. Hadadi A, Farrokhpour H, Rashedi S, Kafan S, Sotoudehnia M, Rahimzadeh H, et al. Long-Term Impact of the COVID-19 Associated AKI: The Relationship between Kidney Recovery and Mortality in a 10-Month Follow-Up Cohort Study. Kidney and Blood Pressure Research. 2022; 47(7): p. 486-491.
37. Parra G, Parra F, Lopez N, Lara A. Chronic kidney disease is a very significant comorbidity for high risk of death in patients with COVID-19 in Mexico. Nephrology. 2021; 26(3): p. 248-251.
38. Dávila R, Jarquín O, Solís-Vallejo A, Nguyen M, Espinoza L. Elevated Monocyte to Lymphocyte Ratio and Increased Mortality among Patients with Chronic Kidney Disease Hospitalized for COVID-19. Journal of Personalized Medicine. 2021; 11(3): p. 1-12.
39. Gibertoni D, Reno C, Rucci P, Fantini M, Buscaroli A. COVID-19 incidence and mortality in non-dialysis chronic kidney disease patients. PLOS ONE. 2021; 16(7).
40. Yan Q, Zuo P, Cheng L, Li Y, Song K, Dai Y, et al. The Journals of Gerontology: Series A. The Journals of Gerontology: Series A. 2021; 76(3): p. 456-462.
41. Ozturk S, Turgutalp K, Arici M, Odabas A, Altiparmak M, Aydin Z, et al. Mortality analysis of COVID-19 infection in chronic kidney disease, haemodialysis and renal transplant patients compared with patients without kidney disease: a nationwide analysis from Turkey. Nephrology Dialysis Transplantation. 2020; 35(12): p. 2083-2095.
42. Trabulus S, Karaca C, Balkan I, Dincer M, Murt A, Ozcan S, et al. Kidney function on admission predicts in-hospital mortality in COVID-19. PLOS ONE. 2020; 15(9): p. 1-14.
43. Parra G, Lopez N, Parra F. Clinical characteristics and risk factors for mortality of patients with COVID-19 in a large data set from Mexico. Annals of Epidemiology. 2020; 52: p. 91-98.
44. Cheng Y, Luo R, Wang K. Kidney disease is associated with in-hospital death of patients with COVID-19. Kidney International. 2020; 97(5): p. 829-838.
45. Chen T, Dai Z, Mo P, Li X, Ma Z, Song S. Clinical Characteristics and Outcomes of Older Patients with Coronavirus Disease 2019 (COVID-19) in Wuhan, China: A Single-Centered, Retrospective Study. The Journals of Gerontology: Series A. 2020; 75(9): p. 1788-1795.
46. Wang L, He W, Yu X, Hu D, Bao M, Liu H. Coronavirus disease 2019 in elderly patients: Characteristics and prognostic factors based on 4-week follow-up. Journal of Infection. 2020; 80(6): p. 639-645.
47. De Francisco Á, Ronco C. Insuficiencia renal aguda en la infección por COVID-19. Sociedad Española de Nefrología. 2021;: p. 1-12.
48. Cheng Y, Luo R, Wang X. The Incidence, Risk Factors, and Prognosis of Acute Kidney Injury in Adult Patients with Coronavirus Disease 2019. Clin J Am Soc Nephrol. 2020; 15(10): p. 1394-1402.
49. Parpas A, Yudd M, Dreisbach A, Michaud J. Post COVID 19 multisystem inflammatory syndrome in an older adult. Renal Failure. 2021; 43(1): p. 530-532.
50. Ron G, Luuk H. CKD is a key risk factor for COVID-19 mortality. Nat Rev Nephrol. 2020; 16(12): p. 705-706.
51. Hilbrands L, Duivenvoorden R, Vart P. COVID-19-related mortality in kidney transplant and dialysis patients: results of the ERACODA collaboration. Nephrol Dial Transplant. 2020; 35(11): p. 1973-1983.
2. OMS. Coronavirus. , Organizacion Mundial de la Salud; 2021.
3. Orús A. Número de casos confirmados de coronavirus en el mundo a fecha de 3 de junio de 2022, por país. Statista, Salud e industria farmacéutica, Estado de salud; 2022.
4. Statista Research Department. Número de casos confirmados de coronavirus (COVID-19) en América Latina y el Caribe al 1 de junio de 2022, por país. Statista, Salud e industria farmacéutica, Estado de salud; 2022.
5. Martin Á, Fernández G. Enfermedad renal en la COVID-19 persistente: un objetivo inmediato para Nefrología. Nefrologia. 2022; 1.
6. Ponce-Lino L, Muñiz-Tóala S, Mastarreno-Cedeño M. Secuelas que enfrentan los pacientes que superan el COVID 19. Revista Cientifica Mundo de la Investigacion y el Conocimiento. 2020 Julio; 4(3): p. 153-162.
7. MSP. Situación epidemiológica nacional Covid-19, Ecuador. Ministerio de Salud Publica , Informes de Situación (SITREP); 2022.
8. Jiang D, McCoy R. Planning for the Post-COVID Syndrome: How Payers Can Mitigate Long-Term Complications of the Pandemic. J Gen Intern Med. 2020 Octubre; 35(10): p. 3036-3039.
9. Del Pino M, Salgueira M, Sanchez J. Registro de la Sociedad Española de Nefrologia sobre IRA en COVID-19. Sociedad Española de Nefrologia. 2021; 1.
10. Stephany L, Caballero-Uribe C, Lewis V. Consideraciones éticas en la publicación de investigaciones científicas. Salud Uninorte. 2017.
11. Organizacion Mundial de la Salud. [Online].; 2022 [cited 2022 Agosto 20. Available from: https://covid19.who.int/.
12. Russo E, Esposito P, Taramasso L, Magnasco L, Saio M, Briano F. Kidney disease and all-cause mortality in patients with COVID-19 hospitalized in Genoa, Northern Italy. Journal of Nephrology. 2021; 34(1): p. 173-183.
13. Chan L, Chaudhary K, Saha A. AKI in Hospitalized Patients with COVID-19. Observational Study. 2021; 32(1).
14. Moledina D, Simonov M, Yamamot Y. The Association of COVID-19 With Acute Kidney Injury Independent of Severity of Illness: A Multicenter Cohort Study. Am J Kidney Dis. 2021; 77(4).
15. Arikan H, Ozturk S, Tokgoz B. Characteristics and outcomes of acute kidney injury in hospitalized COVID-19 patients: A multicenter study by the Turkish society of nephrology. Observational Study. 2021; 16(8).
16. Öztürk S, Turgutalp K, Arıcı M. Impact of hospital-acquired acute kidney injury on Covid-19 outcomes in patients with and without chronic kidney disease: a multicenter retrospective cohort study. Turk J Med Sci. 2021; 28(51).
17. Cassol C, Hannoudi A, Larsen C. A multi-center retrospective cohort study defines the spectrum of kidney pathology in Coronavirus 2019 Disease (COVID-19). Kidney Int. 2021; 100(6).
18. Casas-Aparicio G, León-Rodríguez I, Alvarado-de la Barrera C. Acute kidney injury in patients with severe COVID-19 in Mexico. PLoS One. 2021; 16(2).
19. Costa R, Sória T, Salles E. Acute kidney injury in patients with Covid-19 in a Brazilian ICU: incidence, predictors and in-hospital mortality. J Bras Nefrol. 2021; 43(3).
20. Ryang K, Ri H, Ham Y. Acute Kidney Injury and Kidney Damage in COVID-19 Patients. J Korean Med Sci. 2020; 35(28).
21. Kari J, Shalaby M, Albanna A. Acute kidney injury in children with COVID-19: a retrospective study. BMC. 2021; 22(1).
22. Kolhe N, Fluck R, Nicholas M. Acute kidney injury associated with COVID-19: A retrospective cohort study. PLoS Med. 2020; 17(10): p. e1003406.
23. Zahid U, Ramachandran P, Spita S. Acute Kidney Injury in COVID-19 Patients: An Inner City Hospital Experience and Policy Implications. Soy J Nephrol. 2020; 21(10).
24. Sang L, Chen S, Zheng X. The incidence, risk factors and prognosis of acute kidney injury in severe and critically ill patients with COVID-19 in mainland China: a retrospective study. BMC Pulm Med. 2020; 20(1).
25. Nugent J, Aklilu A, Yamamoto Y, Simonov M, Li F. Assessment of Acute Kidney Injury and Longitudinal Kidney Function After Hospital Discharge Among Patients With and Without COVID-19. JAMA. 2021; 4(3).
26. Bowe B, Cai M, Xie Y, Gibson A, Maddukuri G, Al-Aly Z. Acute kidney injury in a national cohort of hospitalized US veterans with COVID-19. Clinical Journal of the American Society of Nephrology. 2021; 16(1): p. 14-25.
27. Stockmann H, Hardenberg J, Aigner A, Hinze C, Gotthardt I, Stier B, et al. High rates of long-term renal recovery in survivors of coronavirus disease 2019–associated acute kidney injury requiring kidney replacement therapy. Kidney International. 2021; 99(4): p. 1021-1022.
28. Hirsch J, Hazzan A, Wanchoo R, Shah H, Malieckal D, Ross D. Outcomes Among Patients Hospitalized With COVID-19 and Acute Kidney Injury. American Journal of Kidney Diseases. 2021; 77(2): p. 204-215.
29. Bowe B, Xie Y, Xu E. Kidney Outcomes in Long COVID. JASN. 2021; 32(11): p. 2851-2862.
30. Stevens J, King K, Robbins S, Khairallah P, Toma K, Verduzco H. High rate of renal recovery in survivors of COVID-19 associated acute renal failure requiring renal replacement therapy. PLOS ONE. 2020; 15(12).
31. Gameiro J, Fonseca J, Hospitalar C, Norte L, Oliveira J, Marques F, et al. Acute kidney injury in hospitalized patients with COVID-19. Research Square. 2020.
32. Gupta S, Hayek S, Wang W, Chan L, Mathews K, Melamed M, et al. Factors Associated With Death in Critically Ill Patients With Coronavirus Disease 2019 in the US. JAMA Internal Medicine. 2020; 180(11): p. 1436-1447.
33. Kudose S, Batal I, Santoriello D, Xu K, Barasch J, Peleg Y. Kidney Biopsy Findings in Patients with COVID-19. Journal of the American Society of Nephrology. 2020; 31(9): p. 1959-1968.
34. Sharma H, Behera M, Bhadauria D, Khushwaha R, Yachha M. High mortality and residual kidney damage with Coronavirus disease-19-associated acute kidney injury in northern India. Clinical and Experimental Nephrology. 2022;: p. 1-11.
35. Appelman B, Oppelaar J, Broeders L, Wiersinga W, Vogt L, Appelman B. Mortality and readmission rates among hospitalized COVID-19 patients with varying stages of chronic kidney disease: a multicenter retrospective cohort. Scientific Reports. 2022; 12(1): p. 1-8.
36. Hadadi A, Farrokhpour H, Rashedi S, Kafan S, Sotoudehnia M, Rahimzadeh H, et al. Long-Term Impact of the COVID-19 Associated AKI: The Relationship between Kidney Recovery and Mortality in a 10-Month Follow-Up Cohort Study. Kidney and Blood Pressure Research. 2022; 47(7): p. 486-491.
37. Parra G, Parra F, Lopez N, Lara A. Chronic kidney disease is a very significant comorbidity for high risk of death in patients with COVID-19 in Mexico. Nephrology. 2021; 26(3): p. 248-251.
38. Dávila R, Jarquín O, Solís-Vallejo A, Nguyen M, Espinoza L. Elevated Monocyte to Lymphocyte Ratio and Increased Mortality among Patients with Chronic Kidney Disease Hospitalized for COVID-19. Journal of Personalized Medicine. 2021; 11(3): p. 1-12.
39. Gibertoni D, Reno C, Rucci P, Fantini M, Buscaroli A. COVID-19 incidence and mortality in non-dialysis chronic kidney disease patients. PLOS ONE. 2021; 16(7).
40. Yan Q, Zuo P, Cheng L, Li Y, Song K, Dai Y, et al. The Journals of Gerontology: Series A. The Journals of Gerontology: Series A. 2021; 76(3): p. 456-462.
41. Ozturk S, Turgutalp K, Arici M, Odabas A, Altiparmak M, Aydin Z, et al. Mortality analysis of COVID-19 infection in chronic kidney disease, haemodialysis and renal transplant patients compared with patients without kidney disease: a nationwide analysis from Turkey. Nephrology Dialysis Transplantation. 2020; 35(12): p. 2083-2095.
42. Trabulus S, Karaca C, Balkan I, Dincer M, Murt A, Ozcan S, et al. Kidney function on admission predicts in-hospital mortality in COVID-19. PLOS ONE. 2020; 15(9): p. 1-14.
43. Parra G, Lopez N, Parra F. Clinical characteristics and risk factors for mortality of patients with COVID-19 in a large data set from Mexico. Annals of Epidemiology. 2020; 52: p. 91-98.
44. Cheng Y, Luo R, Wang K. Kidney disease is associated with in-hospital death of patients with COVID-19. Kidney International. 2020; 97(5): p. 829-838.
45. Chen T, Dai Z, Mo P, Li X, Ma Z, Song S. Clinical Characteristics and Outcomes of Older Patients with Coronavirus Disease 2019 (COVID-19) in Wuhan, China: A Single-Centered, Retrospective Study. The Journals of Gerontology: Series A. 2020; 75(9): p. 1788-1795.
46. Wang L, He W, Yu X, Hu D, Bao M, Liu H. Coronavirus disease 2019 in elderly patients: Characteristics and prognostic factors based on 4-week follow-up. Journal of Infection. 2020; 80(6): p. 639-645.
47. De Francisco Á, Ronco C. Insuficiencia renal aguda en la infección por COVID-19. Sociedad Española de Nefrología. 2021;: p. 1-12.
48. Cheng Y, Luo R, Wang X. The Incidence, Risk Factors, and Prognosis of Acute Kidney Injury in Adult Patients with Coronavirus Disease 2019. Clin J Am Soc Nephrol. 2020; 15(10): p. 1394-1402.
49. Parpas A, Yudd M, Dreisbach A, Michaud J. Post COVID 19 multisystem inflammatory syndrome in an older adult. Renal Failure. 2021; 43(1): p. 530-532.
50. Ron G, Luuk H. CKD is a key risk factor for COVID-19 mortality. Nat Rev Nephrol. 2020; 16(12): p. 705-706.
51. Hilbrands L, Duivenvoorden R, Vart P. COVID-19-related mortality in kidney transplant and dialysis patients: results of the ERACODA collaboration. Nephrol Dial Transplant. 2020; 35(11): p. 1973-1983.
Publicado
2022-11-26
Cómo citar
Helen Yamileth Parrales Castro, & Narcisa Liliana Durán Ávila. (2022). Secuelas post covid - 19 y mortalidad asociada en pacientes con insuficiencia renal. Revista Científica FIPCAEC (Fomento De La investigación Y publicación científico-técnica multidisciplinaria). ISSN : 2588-090X . Polo De Capacitación, Investigación Y Publicación (POCAIP), 7(4), 1717-1737. https://doi.org/10.23857/fipcaec.v7i4.705
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