Proteinuria y factores de riesgo preexistentes para el desarrollo de preeclampsia en gestantes

  • Stefany Virginia Aguayo Guerrero
  • Nereida Josefina Valero Cedeño
Palabras clave: Diagnóstico; Embarazo; Hipertensión Gestacional; Perinatal; Riesgos.

Resumen

La proteinuria gestacional puede ser parte de los trastornos hipertensivos del embarazo. Son un desafío en especial la preeclampsia, que se presenta como hipertensión de inicio reciente y proteinuria durante el tercer trimestre, puede progresar a complicaciones graves, incluida la muerte materno-fetal. Esta investigación tuvo como objetivo evaluar evidencias científicas actuales sobre la proteinuria y otros factores de riesgo preexistentes para el desarrollo de preeclampsia en gestantes. Se aplicó un diseño documental tipo descriptivo. Se seleccionaron desde bases de datos científicas 85 artículos, publicados entre los años 2018 a 2022. La preeclampsia es un síndrome sistémico que afecta los sistemas cardiovascular, renal y hepático y se asocia con una mayor morbimortalidad materna y perinatal. La proteinuria se utiliza para distinguir la preeclampsia de las condiciones de menor riesgo de hipertensión gestacional y crónica en el embarazo, aunque puede ocurrir en ausencia de proteinuria. Un índice de masa corporal materno más alto, edad más joven, nuliparidad y embarazo gemelar, se asocian de forma independiente con mayores probabilidades de proteinuria en el embarazo. Los trastornos hipertensivos afectan hasta el 10% de las gestantes en todo el mundo, lo que incluye el 3-5% de todos los embarazos complicados con preeclampsia.  A pesar de su prevalencia, los factores de riesgo identificados todavía se mantienen sin precisión para predecir su aparición. La preeclampsia es una de las principales causas de morbilidad materna y se asocia con resultados fetales adversos que incluyen restricción del crecimiento intrauterino, parto prematuro, desprendimiento de placenta, sufrimiento fetal y muerte fetal en el útero. El diagnóstico y manejo oportuno de la preeclampsia implican prevención de los efectos adversos de la prematuridad según la gestación.

Descargas

La descarga de datos todavía no está disponible.

Biografía del autor/a

Stefany Virginia Aguayo Guerrero

Maestría en Ciencias de Laboratorio Clínico, Instituto de Posgrado, Universidad Estatal del Sur de Manabí, Jipijapa, Ecuador.

Nereida Josefina Valero Cedeño

Dra. Mg, PhD, Instituto de Posgrado, Universidad Estatal del Sur de Manabí, Jipijapa, Ecuador.

Citas

1. Filipek A, Jurewicz E. Preeklampsja – choroba kobiet w ciąży [Preeclampsia - a disease of pregnant women]. Postepy Biochem. 2018; 64(4):232-229. Polish. doi: 10.18388/pb.2018_146. PMID: 30656917.
2. World Health Organization. WHO recommendations on antiplatelet agents for the prevention of pre-eclampsia. 2021. Disponible en: https://www.who.int/publications/i/item/9789240037540
3. Rana S, Lemoine E, Granger JP, Karumanchi SA. Preeclampsia: Pathophysiology, Challenges, and Perspectives. Circ Res. 2019;124(7):1094-1112. doi: 10.1161/CIRCRESAHA.118.313276. Erratum in: Circ Res. 2020 Jan 3;126(1):e8. PMID: 30920918.
4. Peraçoli JC, Borges VTM, Ramos JGL, Cavalli RC, Costa SHAM, Oliveira LG, Et al. Pre-eclampsia/Eclampsia. Rev Bras Ginecol Obstet. 2019; 41(5):318-332. English. doi: 10.1055/s-0039-1687859. Erratum in: Rev Bras Ginecol Obstet. 2019;41(5):e1-e2. PMID: 31181585.
5. Mou AD, Barman Z, Hasan M, Miah R, Hafsa JM, Das Trisha A, Ali N. Prevalence of preeclampsia and the associated risk factors among pregnant women in Bangladesh. Sci Rep. 2021;11(1):21339. doi: 10.1038/s41598-021-00839-w. PMID: 34716385; PMCID: PMC8556297.
6. Yang Y, Le Ray I, Zhu J, Zhang J, Hua J, Reilly M. Preeclampsia Prevalence, Risk Factors, and Pregnancy Outcomes in Sweden and China. JAMA Netw Open. 2021; 4(5): e218401. doi: 10.1001/jamanetworkopen.2021.8401. PMID: 33970258; PMCID: PMC8111481.
7. Melchiorre K, Giorgione V, Thilaganathan B. The placenta and preeclampsia: villain or victim? Am J Obstet Gynecol. 2022; 226(2S): S954-S962. doi: 10.1016/j.ajog.2020.10.024. PMID: 33771361.
8. Jirón MGL, Meza ISL, Flores JXD, Vega JXD. La Preclampsia, causa de muerte materna y su evolución en Ecuador durante el periodo 2017 – 2018. RECIAMUC. 2018; 2(2):149-67. Disponible en: https://reciamuc.com/index.php/RECIAMUC/article/view/84
9. Ministerio Salud Pública del Ecuador. Gaceta de Muerte Materna. 2020. Disponible en: https://www.salud.gob.ec/wp-content/uploads/2020/04/MUERTE-MATERNA-SE_15_2020.pdf
10. Camacho-Méndez K, Ventura-Arizmendi E, Zárate A, Hernández-Valencia M. Utilidad de los biomarcadores séricos involucrados en la fisiopatología de la preeclampsia como predictores tempranos de diagnóstico. Perinatología y Reproducción Humana. 2018; 32(1): 39-42. Disponible en: https://www.sciencedirect.com/science/article/pii/S0187533718300384.
11. Hoyert DL, Miniño AM. Maternal Mortality in the United States: Changes in Coding, Publication, and Data Release, 2018. Natl Vital Stat Rep. 2020; 69(2):1-18. PMID: 32510319.
12. Burton GJ, Redman CW, Roberts JM, Moffett A. Pre-eclampsia: pathophysiology and clinical implications. BMJ. 2019; 366: 2381. doi: 10.1136/bmj.l2381. PMID: 31307997.
13. Wadhwani P, Saha PK, Kalra JK, Gainder S, Sundaram V. A study to compare maternal and perinatal outcome in early vs. late onset preeclampsia. Obstet Gynecol Sci. 2020; 63(3):270-277. doi: 10.5468/ogs.2020.63.3.270. PMID: 32489971; PMCID: PMC7231936.
14. Casagrande L, Rezende GP, Guida JP, Costa RS, Parpinelli MA, Surita FG, Costa ML. Maternal and perinatal outcomes related to superimposed pre-eclampsia in a Brazilian cohort of women with chronic hypertension. Int J Gynaecol Obstet. 2020; 149(2):148-153. doi: 10.1002/ijgo.13114. PMID: 32037536.
15. Gomez-Lopez N, Motomura K, Miller D, Garcia-Flores V, Galaz J, Romero R. Inflammasomes: Their Role in Normal and Complicated Pregnancies. J Immunol. 2019; 203(11):2757-2769. doi: 10.4049/jimmunol.1900901. PMID: 31740550; PMCID: PMC6871659.
16. Sultana Z, Maiti K, Dedman L, Smith R. ¿Is there a role for placental senescence in the genesis of obstetric complications and fetal growth restriction? Am J Obstet Gynecol. 2018; 218(2S): S762-S773. doi: 10.1016/j.ajog.2017.11.567. PMID: 29275823.
17. Garrido-Gomez T, Quiñonero A, Dominguez F, Rubert L, Perales A, Hajjar KA, Simon C. Preeclampsia: a defect in decidualization is associated with deficiency of Annexin A2. Am J Obstet Gynecol. 2020; 222(4): 376.e1-376.e17. doi: 10.1016/j.ajog.2019.11.1250. PMID: 31738896.
18. Lip SV, Boekschoten MV, Hooiveld GJ, van Pampus MG, Scherjon SA, Plösch T, Faas MM. Early-onset preeclampsia, plasma microRNAs, and endothelial cell function. Am J Obstet Gynecol. 2020; 222(5): 497.e1-497.e12. doi: 10.1016/j.ajog.2019.11.1286. PMID: 31836544.
19. Genest DS, Dal Soglio D, Girard S, Rey E. Association between proteinuria and placental pathology in preeclampsia: A retrospective study. SAGE Open Med. 2021; 9:20503121211058053. doi: 10.1177/20503121211058053. PMID: 34925835; PMCID: PMC8673865.
20. Tzur Y, Rimon E, Geva G, Herzlich J, Kupferminc MJ. Progression from isolated gestational proteinuria to preeclampsia with severe features. Acta Obstet Gynecol Scand. 2021;100(9):1620-1626. doi: 10.1111/aogs.14198. PMID: 34043807.
21. Rojas Pérez L, Rojas Cruz LA, Villagómez Vega M, Rojas Cruz A, Rojas Cruz AE. Preeclampsia - eclampsia diagnóstico y tratamiento. Revista Eugenio Espejo. 2019; 13(2): 79-91. https://doi.org/10.37135/ee.004.07.09
22. Ciapponi A, Bardach A, Comandé D, Berrueta M, Argento FJ, Rodriguez Cairoli F, Zamora N, Santa María V, Xiong X, Zaraa S, Mazzoni A, Buekens P. COVID-19 and pregnancy: An umbrella review of clinical presentation, vertical transmission, and maternal and perinatal outcomes. PLoS One. 2021;16(6):e0253974. doi: 10.1371/journal.pone.0253974. PMID: 34185807; PMCID: PMC8241118.
23. Allotey J, Stallings E, Bonet M, Yap M, Chatterjee S, Kew T, for PregCOV-19 Living Systematic Review Consortium Etal. Clinical manifestations, risk factors, and maternal and perinatal outcomes of coronavirus disease 2019 in pregnancy: living systematic review and meta-analysis. BMJ. 2020;370:m3320. doi: 10.1136/bmj.m3320. Update in: BMJ. 2022; 377: o1205. PMID: 32873575; PMCID: PMC7459193.
24. Organización Panamericana de la Salud. Estrategias para poner fin a la mortalidad materna prevenible (EPMM) 2020. Disponible en: https://iris.paho.org/bitstream/handle/10665.2/51963/9789275322106-spa.pdf?sequence=1&isAllowed=y
25. Özkara A, Kaya AE, Başbuğ A, Ökten SB, Doğan O, Çağlar M, Kumru S. Proteinuria in preeclampsia: ¿is it important? Ginekol Pol. 2018; 89(5):256-261. doi: 10.5603/GP.a2018.0044. PMID: 30084477.
26. Chimbo Oyaque CE, Mariño Tapia ME, Chimbo Oyaque TA, Caicedo Torres CE. Factores de riesgo y predictores de preeclampsia. Revista Latinoamericana de Hipertensión. 2018; 13(1): 11-18. Disponible en: https://www.revhipertension.com/rlh_1_2018/factores_riesgo_predictores.pdf
27. Fernández Alba JJ, Mesa Páez C, Vilar Sánchez A, Soto Pazos E, González Macías M, Serrano Negro E, Et al. Sobrepeso y obesidad como factores de riesgo de los estados hipertensivos del embarazo: estudio de cohortes retrospectivo. Nutr Hosp. 2018; 35(4): 874-880. https://dx.doi.org/10.20960/nh.1702.
28. Turbeville HR, Sasser JM. Preeclampsia beyond pregnancy: long-term consequences for mother and child. Am J Physiol Renal Physiol. 2020; 318(6): F1315-F1326. doi: 10.1152/ajprenal.00071.2020. PMID: 32249616; PMCID: PMC7311709.
29. Conde-Agudelo A, Romero R. SARS-CoV-2 infection during pregnancy and risk of preeclampsia: a systematic review and meta-analysis. Am J Obstet Gynecol. 2022; 226(1):68-89.e3. doi: 10.1016/j.ajog.2021.07.009. PMID: 34302772; PMCID: PMC8294655.
30. Chadha A, Tayade S. Urinary Protein-to-Creatinine Ratio: An Indicator of Adverse Clinical Outcomes in Preeclampsia With Proteinuria. Cureus. 2022; 14(3):e23341. doi: 10.7759/cureus.23341. PMID: 35464597; PMCID: PMC9017718.
31. Xiao J, Fan W, Zhu Q, Shi Z. Diagnosis of proteinuria using a random urine protein-creatinine ratio and its correlation with adverse outcomes in pregnancy with preeclampsia characterized by renal damage. J Clin Hypertens (Greenwich). 2022; 24(5):652-659. doi: 10.1111/jch.14467. PMID: 35333432; PMCID: PMC9106075.
32. Fishel Bartal M, Lindheimer MD, Sibai BM. Proteinuria during pregnancy: definition, pathophysiology, methodology, and clinical significance. Am J Obstet Gynecol. 2022; 226(2S): S819-S834. doi: 10.1016/j.ajog.2020.08.108. PMID: 32882208.
33. Gerth-Guyette E, Adu-Gyasi D, Tawiah Agyemang C, Bansil P, Barney R, Knudson S, Et al. Evaluation of a protein-to-creatinine dipstick diagnostic test for proteinuria screening in selected antenatal care clinics in three Districts in the Bono-East Region of Ghana. Pregnancy Hypertens. 2022; 30:21-30. doi: 10.1016/j.preghy.2022.07.004. PMID: 35944384.
34. Palacios De Franco Y, Segovia N, Marx Ylbe F, Rudiona H, Franco Palacios C. A Pilot Study of Changes in Urinary Podocalyxin Levels during Normal Pregnancy and Labor. Rom J Intern Med. 2022. doi: 10.2478/rjim-2022-0007. PMID: 35522589.
35. Herlambang H, Puspasari A, Maharani C, Enis RN, Tarawifa S, Fitri AD, Et al. Comprehensive fatty acid fractionation profilling in preeclampsia: a case control study with multivariable analysis. BMC Pregnancy Childbirth. 2022; 22(1):8. doi: 10.1186/s12884-021-04313-3. PMID: 34980007; PMCID: PMC8722156.
36. Pereira Calvo J, Pereira Rodríguez Y, Quirós Figueroa L. Actualización en preeclampsia. Rev Med Sinerg. 2020; 5(1): e340. Disponible en: https://revistamedicasinergia.com/index.php/rms/article/view/340.
37. Bökenkamp A. Proteinuria-take a closer look! Pediatr Nephrol. 2020; 35(4):533-541. doi: 10.1007/s00467-019-04454-w. PMID: 31925536; PMCID: PMC7056687.
38. Ban H, Miura K, Kaneko N, Shirai Y, Yabuuchi T, Ishizuka K, Et al. Amount and selectivity of proteinuria may predict the treatment response in post-transplant recurrence of focal segmental glomerulosclerosis: a single-center retrospective study. Pediatr Nephrol. 2021; 36(8):2433-2442. doi: 10.1007/s00467-021-04951-x. PMID: 33538912.
39. Ives CW, Sinkey R, Rajapreyar I, Tita ATN, Oparil S. Preeclampsia-Pathophysiology and Clinical Presentations: JACC State-of-the-Art Review. J Am Coll Cardiol. 2020; 76(14):1690-1702. doi: 10.1016/j.jacc.2020.08.014. PMID: 33004135.
40. Poon LC, Shennan A, Hyett JA, Kapur A, Hadar E, Divakar H, Et al. The International Federation of Gynecology and Obstetrics (FIGO) initiative on pre-eclampsia: A pragmatic guide for first-trimester screening and prevention. Int J Gynaecol Obstet. 2019;145 Suppl 1(Suppl 1):1-33. doi: 10.1002/ijgo.12802. Erratum in: Int J Gynaecol Obstet. 2019 Sep;146(3):390-391. PMID: 31111484; PMCID: PMC6944283.
41. Mazer Zumaeta A, Wright A, Syngelaki A, Maritsa VA, Da Silva AB, Nicolaides KH. Screening for pre-eclampsia at 11-13 weeks' gestation: use of pregnancy-associated plasma protein-A, placental growth factor or both. Ultrasound Obstet Gynecol. 2020;56(3):400-407. doi: 10.1002/uog.22093. PMID: 32441401.
42. Litwinska M, Litwinska E, Astudillo A, Syngelaki A, Wright A, Nicolaides KH. Stratification of pregnancy care based on risk of pre-eclampsia derived from biophysical and biochemical markers at 19-24 weeks' gestation. Ultrasound Obstet Gynecol. 2021;58(3):360-368. doi: 10.1002/uog.23640. PMID: 33794058.
43. Múnera-Echeverri AG., Muñoz-Ortiz E, Ibarra-Burgos JA. Hipertensión arterial y embarazo. Rev Colomb Cardiol. 2021; 28(1): 3-13. https://doi.org/10.24875/rccar.m21000002.
44. Phipps EA, Thadhani R, Benzing T, Karumanchi SA. Pre-eclampsia: pathogenesis, novel diagnostics and therapies. Nat Rev Nephrol. 2019;15(5):275-289. doi: 10.1038/s41581-019-0119-6. Erratum in: Nat Rev Nephrol. 2019; 15(6):386. PMID: 30792480; PMCID: PMC6472952.
45. Tomimatsu T, Mimura K, Matsuzaki S, Endo M, Kumasawa K, Kimura T. Preeclampsia: Maternal Systemic Vascular Disorder Caused by Generalized Endothelial Dysfunction Due to Placental Antiangiogenic Factors. Int J Mol Sci. 2019;20(17):4246. doi: 10.3390/ijms20174246. PMID: 31480243; PMCID: PMC6747625.
46. Kongwattanakul K, Saksiriwuttho P, Chaiyarach S, Thepsuthammarat K. Incidence, characteristics, maternal complications, and perinatal outcomes associated with preeclampsia with severe features and HELLP syndrome. Int J Womens Health. 2018; 10:371-377. doi: 10.2147/IJWH.S168569. PMID: 30046254; PMCID: PMC6054275.
47. Sufriyana H, Salim HM, Muhammad AR, Wu YW, Su EC. Blood biomarkers representing maternal-fetal interface tissues used to predict early-and late-onset preeclampsia but not COVID-19 infection. Comput Struct Biotechnol J. 2022; 20:4206-4224. doi: 10.1016/j.csbj.2022.08.011. PMID: 35966044; PMCID: PMC9359600.
48. Aminuddin NA, Sutan R, Mahdy ZA, Rahman RA, Nasuruddin DN. The feasibility of soluble Fms-Like Tyrosine kinase-1 (sFLT-1) and Placental Growth Factor (PlGF) ratio biomarker in predicting preeclampsia and adverse pregnancy outcomes among medium to high risk mothers in Kuala Lumpur, Malaysia. PLoS One. 2022;17(3):e0265080. doi: 10.1371/journal.pone.0265080. PMID: 35275947; PMCID: PMC8916650.
49. Reddy M, Palmer K, Rolnik DL, Wallace EM, Mol BW, Da Silva Costa F. Role of placental, fetal and maternal cardiovascular markers in predicting adverse outcome in women with suspected or confirmed pre-eclampsia. Ultrasound Obstet Gynecol. 2022;59(5):596-605. doi: 10.1002/uog.24851. PMID: 34985800.
50. Yeung KR, Sunderland N, Lind JM, Heffernan S, Pears S, Xu B, Hennessy A, Makris A. Increased salt sensitivity in offspring of pregnancies complicated by experimental preeclampsia. Clin Exp Pharmacol Physiol. 2018 Dec;45(12):1302-1308. doi: 10.1111/1440-1681.13008. PMID: 29992611.
51. Brown MA, Magee LA, Kenny LC, Karumanchi SA, McCarthy FP, Saito S, Hall DR, Warren CE, Adoyi G, Ishaku S; International Society for the Study of Hypertension in Pregnancy (ISSHP). Hypertensive Disorders of Pregnancy: ISSHP Classification, Diagnosis, and Management Recommendations for International Practice. Hypertension. 2018;72(1):24-43. doi: 10.1161/HYPERTENSIONAHA.117.10803. PMID: 29899139.
52. Renshall LJ, Cottrell EC, Cowley E, Sibley CP, Baker PN, Thorstensen EB, Greenwood SL, Wareing M, Dilworth MR. Antenatal sildenafil citrate treatment increases offspring blood pressure in the placental-specific Igf2 knockout mouse model of FGR. Am J Physiol Heart Circ Physiol 318: H252–H263, 2020. doi: 10.1152/ajpheart.00568.2019.
53. Morton JS, Levasseur J, Ganguly E, Quon A, Kirschenman R, Dyck JRB, Fraser GM, Davidge ST. Characterisation of the selective reduced uteroplacental perfusion (sRUPP) model of preeclampsia. Sci Rep 2019; 9: 9565. doi: 10.1038/s41598-019-45959-6.
54. Gallo LA, Walton SL, Mazzuca MQ, Tare M, Parkington HC, Wlodek ME, Moritz KM. Uteroplacental insufficiency temporally exacerbates salt-induced hypertension associated with a reduced natriuretic response in male rat offspring. J Physiol. 2018; 596: 5859–5872. doi: 10.1113/JP275655.
55. Kim S, Lee KS, Choi S, Kim J, Lee DK, Park M, Park W, Kim TH, Hwang JY, Won MH, Lee H, Ryoo S, Ha KS, Kwon YG, Kim YM. NF-κB-responsive miRNA-31-5p elicits endothelial dysfunction associated with preeclampsia via down-regulation of endothelial nitric-oxide synthase. J Biol Chem. 2018; 293: 18989–19000. doi: 10.1074/jbc.RA118.005197.
56. Ditisheim A, Wuerzner G, Ponte B, Vial Y, Irion O, Burnier M, Boulvain M, Pechère-Bertschi A. Prevalence of hypertensive phenotypes after preeclampsia: a prospective cohort study. Hypertension. 2018; 71: 103–109. doi: 10.1161/HYPERTENSIONAHA.117.09799.
57. Groom KM, Ganzevoort W, Alfirevic Z, Lim K, Papageorghiou AT; STRIDER Consortium. Clinicians should stop prescribing sildenafil for fetal growth restriction (FGR): comment from the STRIDER Consortium. Ultrasound Obstet Gynecol. 2018; 52: 295–296. doi: 10.1002/uog.19186.
58. Hung TH, Hsieh TT, Chen SF. Risk of abnormal fetal growth in women with early- and late-onset preeclampsia. Pregnancy Hypertens. 2018; 12: 201–206. doi: 10.1016/j.preghy.2017.09.003.
59. Hao J, Hassen D, Hao Q, Graham J, Paglia MJ, Brown J, Cooper M, Schlieder V, Snyder SR. Maternal and infant health care costs related to preeclampsia. Obstet Gynecol 134: 1227–1233, 2019. doi: 10.1097/AOG.0000000000003581.
60. Leaños-Miranda A, Campos-Galicia I, Méndez-Aguilar F, Molina-Pérez CJ, Ramírez-Valenzuela KL, Sillas-Pardo LJ, Et al. Lower circulating angiotensin II levels are related to the severity of preeclampsia and its risk as disclosed by a specific bioassay. Medicine (Baltimore) 2018; 97: e12498. doi: 10.1097/MD.0000000000012498.
61. Cáceres Alvear AS, Garcés García DA, Carpio Cedillo CP. Asociación de riesgo entre periodontitis y preeclampsia. una revisión sistemática retrospectiva. Research, Society and Development. 2021; 10(10): e422101019200. DOI: http://dx.doi.org/10.33448/rsd-v10i10.19200
62. Matsuura T, Shinohara K, Iyonaga T, Hirooka Y, Tsutsui H. Prior exposure to placental ischemia causes increased salt sensitivity of blood pressure via vasopressin production and secretion in postpartum rats. J Hypertens 37: 1657–1667, 2019. doi: 10.1097/HJH.0000000000002091.
63. Ruys CA, Rotteveel J, van de Lagemaat M, Lafeber HN, Finken MJJ. Salt sensitivity of blood pressure at age 8 years in children born preterm. J Hum Hypertens. 2018; 32: 367–376. doi: 10.1038/s41371-018-0045-2
64. Roberge S, Bujold E, Nicolaides KH. Aspirin for the prevention of preterm and term preeclampsia: systematic review and metaanalysis. Am J Obstet Gynecol. 2018; 218: 287–293. Doi: 10.1016/j.ajog.2017.11.561.
65. Albejante MC, Kunz TCM, Ferreira MFC, Júnior JHZR, de Almeida RJ, Bacigalupo LDS, Matheus LHG, Dalboni MA, Camacho CP, Dellê H. Proteinuria is Associated with Urinary Loss of Cubilin and Vitamin D-Binding Protein in Patients with Preeclampsia. Sci Rep. 2020;10(1):3956. doi: 10.1038/s41598-020-60924-4. PMID: 32127613; PMCID: PMC7054416.
66. Armaly Z, Jadaon JE, Jabbour A, Abassi ZA. Preeclampsia: Novel Mechanisms and Potential Therapeutic Approaches. Front Physiol. 2018; 9:973. doi: 10.3389/fphys.2018.00973. PMID: 30090069; PMCID: PMC6068263.
67. Ontano M, Mejía-Velastegui AI, Avilés-Arroyo ME. Principios bioéticos y su aplicación en las investigaciones médico-científicas: Artículo de revisión. Rev Cien Ec. 2021; 3(3):9-16. https://doi.org/10.23936/rce.v3i3.27
68. Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, Et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021; 372:n71. doi: 10.1136/bmj.n71. PMID: 33782057; PMCID: PMC8005924.
69. Salmon L, Mastrolia SA, Hamou B, Wilkof-Segev R, Beer-Weisel R, Klaitman V, Besser L, Erez O. Urine protein-to-creatinine ratio: a point of care for the diagnosis of preeclampsia. Minerva Ginecol. 2018;70(3):246-253. doi: 10.23736/S0026-4784.17.04131-4. PMID: 28994561.
70. Kreepala C, Srila-On A, Kitporntheranunt M, Anakkamatee W, Lawtongkum P, Wattanavaekin K. The Association Between GFR Evaluated by Serum Cystatin C and Proteinuria During Pregnancy. Kidney Int Rep. 2019; 4(6):854-863. doi: 10.1016/j.ekir.2019.04.004. PMID: 31194092; PMCID: PMC6551540.
71. Hofmeyr GJ, Betrán AP, Singata-Madliki M, Cormick G, Munjanja SP, Fawcus S, Mose S, Calcium and Pre-eclampsia Study Group, Et al. Prepregnancy and early pregnancy calcium supplementation among women at high risk of pre-eclampsia: a multicentre, double-blind, randomised, placebo-controlled trial. Lancet. 2019;393(10169):330-339. doi: 10.1016/S0140-6736(18)31818-X. PMID: 30696573; PMCID: PMC6346082.
72. Espinoza Diaz CI, Neira Borja JE, Morocho Zambrano A, Falconez Cobeña K, Freire Wong E, Córdova Vivas M, Et al. Características clínicas y complicaciones asociadas a preeclampsia y eclampsia en pacientes del Hospital General del Norte de Guayaquil IESS Los Ceibos. Revista Latinoamericana de Hipertensión. 2019; 14 (2): 201-204. Disponible en: https://www.revhipertension.com/rlh_2_2019/caracteristicas_clinicas_pacientes.pdf
73. Xu X, Wang Y, Xu H, Kang Y, Zhu Q. Association between proteinuria and maternal and neonatal outcomes in pre-eclampsia pregnancy: a retrospective observational study. J Int Med Res. 2020;48(4):300060520908114. doi: 10.1177/0300060520908114. PMID: 32339047; PMCID: PMC7218474.
74. Stefańska K, Zieliński M, Zamkowska D, Adamski P, Jassem-Bobowicz J, Piekarska K, Et al. Comparisons of Dipstick Test, Urine Protein-to-Creatine Ratio, and Total Protein Measurement for the Diagnosis of Preeclampsia. Int J Environ Res Public Health. 2020; 17(12):4195. doi: 10.3390/ijerph17124195. PMID: 32545523; PMCID: PMC7344421.
75. Akbari A, Kunkel E, Bota SE, Harel Z, Le Gal G, Cox C, Et al. Proteinuria and venous thromboembolism in pregnancy: a population-based cohort study. Clin Kidney J. 2021;14(9):2101-2107. doi: 10.1093/ckj/sfaa278. PMID: 34671466; PMCID: PMC8521786.
76. Mohamed RS, Antonypillai CN, Mahendran H. Paraganglioma presenting as hypertension during pregnancy, proteinuria, thrombocytosis, and diabetes mellitus: a case report. J Med Case Rep. 2021;15(1):352. doi: 10.1186/s13256-021-02923-1. PMID: 34238353; PMCID: PMC8268307.
77. Pasternak Y, Lifshitz D, Shulman Y, Hiersch L, Rimon E, Kuperminc M, Yogev Y, Ashwal E. Diagnostic accuracy of random urinary protein-to-creatinine ratio for proteinuria in patients with suspected pre-eclampsia. Arch Gynecol Obstet. 2021;304(1):109-115. doi: 10.1007/s00404-020-05937-0. PMID: 33386413.
78. Arriaga-García P, Montes-Martínez V. Prevalencia de las categorías de hipertensión inducida por el embarazo que preceden a la eclampsia. Ginecol Obstet Mex. 2021; 89 (5): 364-372.
79. Aynaoğlu Yıldız G, Topdağı Yılmaz EP. The association between protein levels in 24-hour urine samples and maternal and neonatal outcomes of pregnant women with preeclampsia. J Turk Ger Gynecol Assoc. 2022; 23(3):190-198. doi: 10.4274/jtgga.galenos.2022.2022-4-3. PMID: 36065980; PMCID: PMC9450919.
80. Golovchenko OV, Abramova MY, Orlova VS, Batlutskaya IV, Sorokina IN. Clinical and Genetic Characteristics of Preeclampsia. Arch Razi Inst. 2022;77(1):293-299. doi: 10.22092/ARI.2021.356481.1852. PMID: 35891763; PMCID: PMC9288621.
81. Mrema D, Lie RT, Østbye T, Mahande MJ, Daltveit AK. The association between pre pregnancy body mass index and risk of preeclampsia: a registry based study from Tanzania. BMC Pregnancy Childbirth. 2018;18(1):56. doi: 10.1186/s12884-018-1687-3. PMID: 29466949; PMCID: PMC5822591.
82. Nguefack CT, Ako MA, Dzudie AT, Nana TN, Tolefack PN, Mboudou E. Comparison of materno-fetal predictors and short-term outcomes between early and late onset pre-eclampsia in the low-income setting of Douala, Cameroon. Int J Gynaecol Obstet. 2018; 142(2):228-234. doi: 10.1002/ijgo.12531. PMID: 29761476.
83. Grum T, Hintsa S, Hagos G. Dietary factors associated with preeclampsia or eclampsia among women in delivery care services in Addis Ababa, Ethiopia: a case control study. BMC Res Notes. 2018;11(1):683. doi: 10.1186/s13104-018-3793-8. PMID: 30285827; PMCID: PMC6167851.
84. Musa J, Mohammed C, Ocheke A, Kahansim M, Pam V, Daru P. Incidence and risk factors for pre-eclampsia in Jos Nigeria. Afr Health Sci. 2018;18(3):584-595. doi: 10.4314/ahs.v18i3.16. PMID: 30602991; PMCID: PMC6307024.
85. Olalere FDH, Okusanya BO, Oye-Adeniran BA. Maternal serum lipid in women with preeclampsia in Lagos: a case control study. J Matern Fetal Neonatal Med. 2020;33(5):794-798. doi: 10.1080/14767058.2018.1505851. PMID: 30176753.
86. Ahmed NA, Adam I, Elzaki SEG, Awooda HA, Hamdan HZ. Factor-V Leiden G1691A and prothrombin G20210A polymorphisms in Sudanese women with preeclampsia, a case -control study. BMC Med Genet. 2019; 20(1):2. doi: 10.1186/s12881-018-0737-z. PMID: 30611230; PMCID: PMC6321713.
87. Ahmed MA, Hassan NG, Omer ME, Rostami A, Rayis DA, Adam I. Helicobacter pylori and Chlamydia trachomatis in Sudanese women with preeclampsia. J Matern Fetal Neonatal Med. 2020; 33(12):2023-2026. doi: 10.1080/14767058.2018.1536738. PMID: 30318949.
88. Alese MO, Moodley J, Naicker TA. Signalling of ERK1/2, P38MAPK and P90RSK in HIV-associated pre-eclampsia. J Obstet Gynaecol. 2019; 39(5):612-618. doi: 10.1080/01443615.2018.1547695. PMID: 30821550.
89. Belay AS, Wudad T. Prevalence and associated factors of pre-eclampsia among pregnant women attending anti-natal care at Mettu Karl referal hospital, Ethiopia: cross-sectional study. Clin Hypertens. 2019; 25:14. doi: 10.1186/s40885-019-0120-1. PMID: 31304042; PMCID: PMC6600877.
90. Elzein HO, Saad AA, Yousif AA, Elamin E, Abdalhabib EK, Elzaki SG. Evaluation of Factor V Leiden and prothrombin G20210A mutations in Sudanese women with severe preeclampsia. Curr Res Transl Med. 2020; 68(2):77-80. doi: 10.1016/j.retram.2019.08.002. PMID: 31501046.
91. Mahmoud S, Nasri H, Nasr AM, Adam I. Maternal and umbilical cord blood level of macrophage migration inhibitory factor and insulin like growth factor in Sudanese women with preeclampsia. J Obstet Gynaecol. 2019; 39(1):63-67. doi: 10.1080/01443615.2018.1473350. PMID: 30286674.
92. Motedayen M, Rafiei M, Rezaei Tavirani M, Sayehmiri K, Dousti M. The relationship between body mass index and preeclampsia: A systematic review and meta-analysis. Int J Reprod Biomed. 2019;17(7):463-472. doi: 10.18502/ijrm.v17i7.4857. PMID: 31508571; PMCID: PMC6718883.
93. Ahmed SF, Ali MM, Kheiri S, Elzaki SEG, Adam I. Association of methylenetetrahydrofolate reductase C677T and reduced-f carrier-1 G80A gene polymorphism with preeclampsia in Sudanese women. Hypertens Pregnancy. 2020;39(2):77-81. doi: 10.1080/10641955.2020.1725037. PMID: 32013623.
94. Hamid HM, Abdalla SE, Sidig M, Adam I, Hamdan HZ. Association of VEGFA and IL1β gene polymorphisms with preeclampsia in Sudanese women. Mol Genet Genomic Med. 2020; 8(3):e1119. doi: 10.1002/mgg3.1119. PMID: 31943890; PMCID: PMC7057117.
95. Okoror CEM, Enabudoso EJ, Okoror OT, Okonkwo CA. Serum calcium-magnesium ratio in women with pre-eclampsia at a tertiary hospital in Nigeria. Int J Gynaecol Obstet. 2020; 149(3):354-358. doi: 10.1002/ijgo.13142. PMID: 32167585.
96. Wu Y, Liu Y, Ding Y. Predictive Performance of Placental Protein 13 for Screening Preeclampsia in the First Trimester: A Systematic Review and Meta-Analysis. Front Med (Lausanne). 2021; 8:756383. doi: 10.3389/fmed.2021.756383. PMID: 34869456; PMCID: PMC8640131.
97. Al Khalaf SY, O'Reilly ÉJ, Barrett PM, B Leite DF, Pawley LC, McCarthy FP, Khashan AS. Impact of Chronic Hypertension and Antihypertensive Treatment on Adverse Perinatal Outcomes: Systematic Review and Meta-Analysis. J Am Heart Assoc. 2021;10(9):e018494. doi: 10.1161/JAHA.120.018494. Epub 2021 Apr 17. PMID: 33870708; PMCID: PMC8200761.
98. Spadarella E, Leso V, Fontana L, Giordano A, Iavicoli I. Occupational Risk Factors and Hypertensive Disorders in Pregnancy: A Systematic Review. Int J Environ Res Public Health. 2021;18(16):8277. doi: 10.3390/ijerph18168277. PMID: 34444025; PMCID: PMC8392340.
99. Huang T, Bedford HM, Rashid S, Rasasakaram E, Priston M, Mak-Tam E, Gibbons C, Meschino WS, Cuckle H, Mei-Dan E. Modified multiple marker aneuploidy screening as a primary screening test for preeclampsia. BMC Pregnancy Childbirth. 2022;22(1):190. doi: 10.1186/s12884-022-04514-4. PMID: 35260099; PMCID: PMC8903171.
100. Marchand G, Patil AS, Masoud AT, Ware K, King A, Ruther S, Brazil G, Calteux N, Ulibarri H, Parise J, Arroyo A, Coriell C, Cook C, Ruuska A, Nourelden AZ, Sainz K. Systematic review and meta-analysis of COVID-19 maternal and neonatal clinical features and pregnancy outcomes up to June 3, 2021. AJOG Glob Rep. 2022; 2(1):100049. doi: 10.1016/j.xagr.2021.100049. PMID: 35005663; PMCID: PMC8720679.
101. McKenzie KA, Trotman H. A Retrospective Study of Neonatal Outcome in Preeclampsia at the University Hospital of the West Indies: A Resource-limited Setting. J Trop Pediatr. 2019; 65(1):78-83. doi: 10.1093/tropej/fmy014. PMID: 29590467.
102. Dravet-Gounot P, Torchin H, Goffinet F, Aubelle MS, El Ayoubi M, Lefevre C, Jarreau PH, Zana-Taïeb E. Bronchopulmonary dysplasia in neonates born to mothers with preeclampsia: Impact of small for gestational age. PLoS One. 2018; 13(9): e0204498. doi: 10.1371/journal.pone.0204498. PMID: 30248159; PMCID: PMC6152970.
103. Kanonge TI, Chamunyonga F, Zakazaka N, Chidakwa C, Madziyire MG. Hepatic rupture from haematomas in patients with pre-eclampsia/eclampsia: a case series. Pan Afr Med J. 2018; 31:86. doi: 10.11604/pamj.2018.31.86.15975. PMID: 31011387; PMCID: PMC6462150.
104. Melese MF, Badi MB, Aynalem GL. Perinatal outcomes of severe preeclampsia/eclampsia and associated factors among mothers admitted in Amhara Region referral hospitals, North West Ethiopia, 2018. BMC Res Notes. 2019;12(1):147. doi: 10.1186/s13104-019-4161-z. PMID: 30876447; PMCID: PMC6420725.
105. Bridwell M, Handzel E, Hynes M, Jean-Louis R, Fitter D, Hogue C, Grand-Pierre R, Pierre H, Pearce B. Hypertensive disorders in pregnancy and maternal and neonatal outcomes in Haiti: the importance of surveillance and data collection. BMC Pregnancy Childbirth. 2019;19(1):208. doi: 10.1186/s12884-019-2361-0. PMID: 31221123; PMCID: PMC6585002.
106. Coviello EM, Iqbal SN, Grantz KL, Huang CC, Landy HJ, Reddy UM. Early preterm preeclampsia outcomes by intended mode of delivery. Am J Obstet Gynecol. 2019; 220(1): 100.e1-100.e9. doi: 10.1016/j.ajog.2018.09.027. PMID: 30273585; PMCID: PMC7605098.
107. Venkatesh KK, Strauss RA, Westreich DJ, Thorp JM, Stamilio DM, Grantz KL. Adverse maternal and neonatal outcomes among women with preeclampsia with severe features <34 weeks gestation with versus without comorbidity. Pregnancy Hypertens. 2020; 20:75-82. doi: 10.1016/j.preghy.2020.03.006. PMID: 32193149; PMCID: PMC7293899.
108. Ndwiga C, Odwe G, Pooja S, Ogutu O, Osoti A, E Warren C. Clinical presentation and outcomes of pre-eclampsia and eclampsia at a national hospital, Kenya: A retrospective cohort study. PLoS One. 2020; 15(6):e0233323. doi: 10.1371/journal.pone.0233323. PMID: 32502144; PMCID: PMC7274433.
109. Mengistu MD, Kuma T. Feto-maternal outcomes of hypertensive disorders of pregnancy in Yekatit-12 Teaching Hospital, Addis Ababa: a retrospective study. BMC Cardiovasc Disord. 2020;20(1):173. doi: 10.1186/s12872-020-01399-z. PMID: 32293281; PMCID: PMC7161304.
110. Belay Tolu L, Yigezu E, Urgie T, Feyissa GT. Maternal and perinatal outcome of preeclampsia without severe feature among pregnant women managed at a tertiary referral hospital in urban Ethiopia. PLoS One. 2020;15(4): e0230638. doi: 10.1371/journal.pone.0230638. PMID: 32271787; PMCID: PMC7144970.
111. Dassah ET, Kusi-Mensah E, Morhe ESK, Odoi AT. Maternal and perinatal outcomes among women with hypertensive disorders in pregnancy in Kumasi, Ghana. PLoS One. 2019; 14(10):e0223478. doi: 10.1371/journal.pone.0223478. PMID: 31584982; PMCID: PMC6777792.
112. Panda S, Das R, Sharma N, Das A, Deb P, Singh K. Maternal and Perinatal Outcomes in Hypertensive Disorders of Pregnancy and Factors Influencing It: A Prospective Hospital-Based Study in Northeast India. Cureus. 2021; 13(3):e13982. doi: 10.7759/cureus.13982. PMID: 33880307; PMCID: PMC8053022.
113. Molina RL, Tsai TC, Dai D, Soto M, Rosenthal N, Orav EJ, Figueroa JF. Comparison of Pregnancy and Birth Outcomes Before vs During the COVID-19 Pandemic. JAMA Netw Open. 2022; 5(8):e2226531. doi: 10.1001/jamanetworkopen.2022.26531. Erratum in: JAMA Netw Open. 2022 Sep 1;5(9):e2233824. PMID: 35960517; PMCID: PMC9375166.
114. Gurol-Urganci I, Waite L, Webster K, Jardine J, Carroll F, Dunn G, Frémeaux A, Harris T, Hawdon J, Muller P, van der Meulen J, Khalil A. Obstetric interventions and pregnancy outcomes during the COVID-19 pandemic in England: A nationwide cohort study. PLoS Med. 2022; 19(1):e1003884. doi: 10.1371/journal.pmed.1003884. PMID: 35007282; PMCID: PMC8803187.
115. ACOG Practice Bulletin No. 202: Gestational Hypertension and Preeclampsia. Obstet Gynecol. 2019; 133(1):1. doi: 10.1097/AOG.0000000000003018. PMID: 30575675.
116. Lei T, Qiu T, Liao W, Li K, Lai X, Huang H, Yuan R, Chen L. Proteinuria may be an indicator of adverse pregnancy outcomes in patients with preeclampsia: a retrospective study. Reprod Biol Endocrinol. 2021; 19(1):71. doi: 10.1186/s12958-021-00751-y. PMID: 33990220; PMCID: PMC8120921.
117. Núñez A, Sreeganga SD, Ramaprasad A. Access to Healthcare during COVID-19. Int J Environ Res Public Health. 2021; 18(6):2980. doi: 10.3390/ijerph18062980. PMID: 33799417; PMCID: PMC7999346.
118. Crump C, Sundquist J, Sundquist K. Risk of hypertension into adulthood in persons born prematurely: a national cohort study. Eur Heart J. 2020;41(16):1542-1550. doi: 10.1093/eurheartj/ehz904. PMID: 31872206; PMCID: PMC8453271
Publicado
2022-11-19
Cómo citar
Stefany Virginia Aguayo Guerrero, & Nereida Josefina Valero Cedeño. (2022). Proteinuria y factores de riesgo preexistentes para el desarrollo de preeclampsia en gestantes. Revista Científica FIPCAEC (Fomento De La investigación Y publicación científico-técnica multidisciplinaria). ISSN : 2588-090X . Polo De Capacitación, Investigación Y Publicación (POCAIP), 7(4), 311-349. Recuperado a partir de https://fipcaec.com/index.php/fipcaec/article/view/638
Sección
Artículos de Investigación