Concentraciones de dímero d y tiempo de protrombina en pacientes hospitalizados por covid-19
Abstract
La crisis sanitaria por la COVID-19, debido a su rápida expansión y al poco conocimiento de esta nueva enfermedad, ocasionó la muerte de gran cantidad de personas alrededor del mundo, motivo por el cual se ha generado la necesidad de identificar posibles biomarcadores que permitan dar un pronóstico de la gravedad de esta infección. El objetivo del presente estudio fue analizar las concentraciones de dímero D y el tiempo de protrombina como pronóstico de letalidad en pacientes hospitalizados con COVID-19. El estudio consistió en una investigación de diseño documental con carácter descriptivo y exploratorio el cual permitió seleccionar artículos publicados año 2018-2022, seleccionados bajo criterios de inclusión y exclusión de bases de datos científicas. Se evidencia una correlación en la alteración de los valores de dímero D, con la tasa de letalidad del 65,77% que se encontró en promedio en los diferentes estudios. La fisiopatología de la COVID-19 incluye en algunos individuos el desarrollo de una sobre regulación del proceso inflamatorio con la consecuente tormenta de citoquinas que favorece la activación de la cascada de coagulación, las alteraciones en las concentraciones del dímero D se encuentran relacionados con casos graves y en especial ante la presencia de comorbilidades subyacentes.
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References
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7. Cummings, M. J., Baldwin, M. R., Abrams, D., Jacobson, S. D., Meyer, B. J., Balough, E. M., Aaron, J. G., Claassen, J., Rabbani, L. R. E., Hastie, J., Hochman, B. R., Salazar-Schicchi, J., Yip, N. H., Brodie, D., & O’Donnell, M. R. (2020b). Epidemiology, clinical course, and outcomes of critically ill adults with Covid-19 in New York City: A prospective cohort study. The Lancet, 395(10239), 1763-1770. https://doi.org/10.1016/S0140-6736(20)31189-2
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14. Giannis, D., Ziogas, I. A., & Gianni, P. (2020). Coagulation disorders in coronavirus infected patients: COVID-19, SARS-CoV-1, MERS-CoV and lessons from the past. Journal of Clinical Virology, 127, 104362. https://doi.org/10.1016/j.jcv.2020.104362
15. Han, H., Yang, L., Liu, R., Liu, F., Liu, F., Wu, K. L., Li, J., Liu, X. H., & Zhu, C. L. (2020). Prominent changes in blood coagulation of patients with SARS-CoV-2 infection. Clinical chemistry and laboratory medicine, 58(7), 1116-1120. https://doi.org/10.1515/CCLM-2020-0188
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21. Liao, J., Fan, S., Chen, J., Wu, J., Xu, S., Guo, Y., Li, C., Zhang, X., Wu, C., Mou, H., Song, C., Li, F., Wu, G., Zhang, J., Guo, L., Liu, H., Lv, J., Xu, L., & Lang, C. (2020). Epidemiological and Clinical Characteristics of COVID-19 in Adolescents and Young Adults. The Innovation, 1(1), 100001. https://doi.org/10.1016/j.xinn.2020.04.001
22. Lippi, G., Lavie, C. J., & Sanchis-Gomar, F. (2020). Cardiac troponin I in patients with coronavirus disease 2019 (Covid-19): Evidence from a meta-analysis. En Progress in Cardiovascular Diseases (Vol. 63, Número 3, pp. 390-391). Elsevier. https://doi.org/10.1016/j.pcad.2020.03.001
23. Long, H., Nie, L., Xiang, X., Li, H., Zhang, X., Fu, X., Ren, H., Liu, W., Wang, Q., & Wu, Q. (2020). D-Dimer and Prothrombin Time Are the Significant Indicators of Severe Covid-19 and Poor Prognosis. BioMed Research International, 2020. https://doi.org/10.1155/2020/6159720
24. Mehta, P., McAuley, D. F., Brown, M., Sanchez, E., Tattersall, R. S., & Manson, J. J. (2020). COVID-19: Consider cytokine storm syndromes and immunosuppression. The Lancet, 395(10229), 1033-1034. https://doi.org/10.1016/S0140-6736(20)30628-0
25. Moreno, G., Carbonell, R., Bodí, M., & Rodríguez, A. (2021). Systematic review of the prognostic utility of D-dimer, disseminated intravascular coagulation, and anticoagulant therapy in Covid-19 critically ill patients. Medicina Intensiva, 45(1), 42-55. https://doi.org/10.1016/j.medin.2020.06.006
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Published
2022-11-20
How to Cite
Angélica Yesenia Rodas Toapanta, & Yoiler Batista Garcet. (2022). Concentraciones de dímero d y tiempo de protrombina en pacientes hospitalizados por covid-19. Revista Cien´tifica FIPCAEC (Fomento De La investigación Y publicación En Ciencias Administrativas, Económicas Y Contables), 7(4), 1155-1177. Retrieved from https://fipcaec.com/index.php/fipcaec/article/view/678
Section
Artículos de Investigación
