Concentraciones séricas de interleuquina 6 y su valor pronóstico de letalidad en adultos mayores con Covid-19
Palabras clave:
Citoquinas proinflamatorias; SARS-CoV-2; adultos mayores; factores de riesgo; pandemia; mortalidad.
Resumen
La pandemia de COVID-19, ha afectado a todas las edades, etnias o género. El Objetivo del estudio fue analizar evidencias científicas sobre las concentraciones séricas de la interleuquina 6 (IL-6) y su valor pronóstico de letalidad en adultos mayores con COVID-19. El diseño es documental con bibliográficas en PubMed, Elsevier, Google Académico, SciELO, Scopus, Biblioteca Cochrane, Web of Science de entes de salud. Se seleccionaron 116 artículos bajo criterios de inclusión y exclusión, publicados en el periodo 2020-2022. En la frecuencia de mortalidad en adultos mayores con COVID-19 fue evidente una variabilidad entre intrapaíses que permitió ubicarla en el rango de 3 al 75% en adultos mayores de 60 años, aunque se ha observado una disminución de la letalidad por COVID-19 al compararla con la observada al inicio de la pandemia. Las concentraciones séricas de interleuquina 6 (IL-6) en adultos mayores según el grado de severidad de la infección, evidenciaron rangos de detección desde 1,62 a 7,52 pg/L en pacientes no graves, mientras que en pacientes graves el rango de las concentraciones séricas de IL-6 fue desde 4,83 a 23,4 pg/L, estrechamente relacionada con la severidad y mayor letalidad de los casos graves.
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Publicado
2022-11-19
Cómo citar
Nelly Isabel Amaiquema Marquez, & Augusto Leonel Durán Cañarte. (2022). Concentraciones séricas de interleuquina 6 y su valor pronóstico de letalidad en adultos mayores con Covid-19. Revista Científica FIPCAEC (Fomento De La investigación Y publicación científico-técnica multidisciplinaria). ISSN : 2588-090X . Polo De Capacitación, Investigación Y Publicación (POCAIP), 7(4), 722-757. Recuperado a partir de https://fipcaec.com/index.php/fipcaec/article/view/658
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